Synthetic Route of 306960-77-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 306960-77-0, name is 2-(Trifluoromethyl)pyrimidine-5-carboxylic acid, molecular formula is C6H3F3N2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
2-(Trifluoromethyl)pyrimidine-5-carboxylic acid (44.39 g, 231 .1 mmol),methoxymethanine hydrochloride (33.8 g, 346.6 mmol) and DIPEA (119.5 mL, 924.3 mmol) were combined in DCM (750 mL) then HATU (105.4 g, 277.3 mmol) was added and the mixture stirred at RT for 2 h. The reaction mixture was washed with water (3 x 300 mL), the organic phase collected, dried (over Mg504), filtered andconcentrated in vacuo to give a viscous yellow oil. The crude material was purified by dry flash chromatography (eluting with 0 – 40 % EtOAc in heptane) to give 54.2 g (95% yield) of the title compound as a free flowing pale yellow oil.1H NMR (500 MHz, Chloroform-d): 6 [ppm] 9.22 (5, 2H), 3.61 (5, 3H), 3.43 (5, 3H). LCMS (Analytical Method A) Rt = 1 .03 mm, MS (ESipos): m/z = 235.9 (M+H).
According to the analysis of related databases, 306960-77-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; EVOTEC AG; DAVENPORT, Adam James; BRAEUER, Nico; FISCHER, Oliver Martin; ROTGERI, Andrea; ROTTMANN, Antje; NEAGOE, Ioana; NAGEL, Jens; GODINHO-COELHO, Anne-Marie; (703 pag.)WO2016/91776; (2016); A1;,
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