Adding a certain compound to certain chemical reactions, such as: 3167-50-8, 2-Aminopyrimidine-5-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines
To 1.9 g of polyphosphoric acid were added 500 mg (3.59 mmol) of 2-aminopyrimidine-5-carboxylic acid portionwise. It was stirred for 5 mm before 327.6 mg (3.59 mmol) of hydrazinecarbothioamide were added portionwise. It was stirred for 1 h at 140 C. It was allowed to cool down and water was added. The pH was adjusted to 12 by adding 25 vol% aqueous ammonia solution. The precipitate wasfiltered off and washed with water. It was dried under vacuum at 50 C to yield 164 mg (23%) of the title compound, containing ca. 25 mol% of the starting material.?H-NMR (300MHz, DMSO-d6): 6 [ppm]= 7.13 (s, 2H), 7.30 (s, 2H), 8.56 (s, 2H).LC-MS (Method 3): R = 0.44 mm; MS (ESIpos): m/z = 195 [M+H].
At the same time, in my other blogs, there are other synthetic methods of this type of compound,3167-50-8, 2-Aminopyrimidine-5-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; THEDE, Kai; BENDER, Eckhard; SCOTT, William; RICHTER, Anja; ZORN, Ludwig; LIU, Ningshu; MOeNNING, Ursula; SIEGEL, Franziska; GOLZ, Stefan; HAeGEBARTH, Andrea; LIENAU, Philip; PUEHLER, Florian; BASTING, Daniel; SCHNEIDER, Dirk; MOeWES, Manfred; GEISLER, Jens; WO2015/140195; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia