Application of 32980-71-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.32980-71-5, name is Perchloropyrimido[5,4-d]pyrimidine, molecular formula is C6Cl4N4, molecular weight is 269.9, as common compound, the synthetic route is as follows.
Connect a mineral oil valve rotating device, an impregnation thermometer, to a 4-cc bottle with a capacity of 100 cc.a vent and a drying tube, Add 7g piperidine and 30cc absolute ethanol to the bottle. Then, 2.7 g of tetrachloropyrimidopyrimidine was added with stirring. Increasing the reaction temperature to 32-35 C produces a moderate amount of basic steam. The powder reaction gradually changes from a yellow-gold-red crystal powder to a transparent granular powder.The tetrachloro compound is gradually added in 30 minutes. The reaction mixture was continuously stirred for 90 minutes and then allowed to stand for 24 hours. After the reaction was completed, it was observed that there was a bright yellow powder in the bright orange liquid, and the color of the liquid became more vivid when it was left standing. The precipitate was collected by filtration and washed with absolute ethanol to give 3.24 g of a yellow powder of unknown melting point which softened at 180 C and rapidly melted and decomposed at 240 C.The yellow powder was purified by adding 30 cc of dimethylformamide precooled at 0 C, and the dimethylformamide was turned into a deep red color. The precipitate was collected by suction filtration using a vacuum suction apparatus, and the residual dimethyl group was removed by washing with 10 cc of absolute ethanol. Formamide,The weight of the product is less than half the weight of the original material.The melting point is raised to 245 ~ 255 C, And softening occurs at 225 C. The average yield of the two chlorination reactions and subsequent reaction with piperidine is from 27 to 29%, based on the piperidine derivative, wherein the oxidized uric acid used in the chlorination reaction stage is in the form of its dried disodium salt.
Statistics shows that 32980-71-5 is playing an increasingly important role. we look forward to future research findings about Perchloropyrimido[5,4-d]pyrimidine.
Reference:
Patent; Suohao; Huan Xiaojun; Suo Hao; Qi Taotao; Jin Chunyan; Chen Yifei; (9 pag.)CN108752350; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia