In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3435-25-4, name is 4-Chloro-6-methylpyrimidine, the common compound, a new synthetic route is introduced below. name: 4-Chloro-6-methylpyrimidine
Make BA-1 (1.00 g, 7.78 mmol)And Ni(dppe)Cl2 (82 mg, 0.16 mmol)The solution in anhydrous Et 2 O (5 mL) was cooled to -10 C.Then, n-propyl magnesium bromide was added dropwise and the mixture was stirred at -10 C for 2 h.The mixture was quenched with saturated aq. The crude BA-2 can be used without further processing.
The synthetic route of 3435-25-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BAKONYI,JOHANNA; BRUNETTE,STEVEN RICHARD; COLLIN,DELPHINE; HUGHES,ROBERT OWEN; LI,XIANG; LIANG,SHUANG; SIBLEY,ROBERT; TURNER,MICHAEL ROBERT; WU,LIFEN; ZHANG,QIANG; (169 pag.)TW2018/38997; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia