In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Solvent-free N-Boc deprotection by ex situ generation of hydrogen chloride gas, published in 2021, which mentions a compound: 35621-01-3, mainly applied to amine hydrochloride salt preparation green chem; tertbutyl carbamate deprotection, Reference of Piperidin-4-amine dihydrochloride.
An efficient, scalable and sustainable method for the quant. deprotection of the tert-Bu carbamate (N-Boc) protecting group is described, using down to near-stoichiometric amounts of hydrogen chloride gas in solvent-free conditions. The ex situ generation of hydrogen chloride gas from sodium chloride and sulfuric acid in a two-chamber reactor, introducing a straightforward method for controlled and stoichiometric release of HCl gas were demonstrated. The solvent-free conditions allow deprotection of a wide variety of N-Boc derivatives e.g., N-Boc benzylamine to obtain the hydrochloride salts in e.g., benzylamine hydrochloride quant. yields. The procedure obviates the need for any work-up or purification steps providing an uncomplicated green alternative to standard methods. Due to the solvent-free, anhydrous conditions, this method shows high tolerance towards acid sensitive functional groups and furnishes expanded functional group orthogonality.
Although many compounds look similar to this compound(35621-01-3)Reference of Piperidin-4-amine dihydrochloride, numerous studies have shown that this compound(SMILES:NC1CCNCC1.[H]Cl.[H]Cl), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia