Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 3680-71-5, Name is 1,7-Dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, molecular formula is , belongs to pyrimidines compound. In a document, author is Sun, Yan, Safety of 1,7-Dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one.
Discovery of new thieno[2,3-d]pyrimidine and thiazolo[5,4-d]pyrimidine derivatives as orally active phosphoinositide 3-kinase inhibitors
As abnormal PI3K signaling is a feature of many types of cancer, the development of orally active PI3K inhibitors is of great significance for targeted cancer therapy. Through integrating strategies of reducing aromatic character/increasing the fraction of sp(3) carbons together with scaffold hopping, we designed and synthesized two new series of thieno[2,3-d]pyrimidine and thiazolo[5,4-d]pyrimidine derivatives for use as PI3K inhibitors. Our structure-activity relationship studies led to the identification of thieno[2,3-d]pyrimidine 6a and thiazolo [5,4-d] pyrimidine 7a, which exhibited remarkable nanomolar PI3K potency, good antipmliferative activity, favorable pharmacokinetic properties and significant in vivo anti-cancer efficacy. Notably, thiazolo [5,4-d]pyrimidine 7a had better anti-cancer activity than thieno [2,3-d]pyrimidine 6a and is worthy of further pre-clinical evaluation for its use in cancer treatment.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 3680-71-5, in my other articles. Safety of 1,7-Dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one.
Reference:
Pyrimidine | C4H4N2 – PubChem,
,Pyrimidine – Wikipedia