Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3740-92-9, name is 4,6-Dichloro-2-phenylpyrimidine. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C10H6Cl2N2
4,6-Dichloro-2-phenylpyrimidine (5.0 g, 22.2 mmol) and NaOCH3 (3.6 g, 66.6 mmol) was stirred in methanol (500 mL) on an ice bath for 1 h, then brought to reflux for 7 h. After evaporation, the white solid was dissolved in DCM (100 mL) and washed with water. Evaporation of the organic phase yielded 8 (3.98 g, 81%) as a white solid. 1H NMR (CD3OD): delta 8.39-8.36 (m, 2H), 7.53-7.44 (m, 3H), 6.76 (s, 1H), 4.08 (s, 3H). 13C NMR (CD3OD): delta 172.3, 165.9, 162.2, 137.4, 132.6, 129.5, 129.5, 106.0, 55.0. MS calcd for C11H9ClN2O [M+H]+ 221.0, found: 221.0.
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Reference:
Article; Lampa, Anna; Alogheli, Hiba; Ehrenberg, Angelica E.; Akerblom, Eva; Svensson, Richard; Artursson, Per; Danielson, U. Helena; Karlen, Anders; Sandstroem, Anja; Bioorganic and Medicinal Chemistry; vol. 22; 23; (2014); p. 6595 – 6615;,
Pyrimidine | C4H4N2 – PubChem,
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