Some scientific research about 39906-04-2

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 39906-04-2, 4,6-Dichloro-2-methylpyrimidin-5-amine, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 39906-04-2, Adding some certain compound to certain chemical reactions, such as: 39906-04-2, name is 4,6-Dichloro-2-methylpyrimidin-5-amine,molecular formula is C5H5Cl2N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 39906-04-2.

4-Chloro-6-(2-fluoro-4-trifluoromethyl-phenyl)-2-methyl-pyhmidin-5-ylamine (Intermediate compound 4) To a solution of commercially available 5-amino-4,6-dichloro-2- methylpyrimidine (2.500 g, 15.2444 mmol) in DME (100 ml) and water (20 ml), 2- fluoro-4-(thfluoromethyl)phenylboronic acid (3.1696 g, 15.2444 mmol) and sodium carbonate (4.847 g, 45.7332 mmol) were added. The reaction mixture was degassed and kept under nitrogen atmosphere during the entire course of the reaction. Palladium (II) (bistriphenylphosphine)dichlohde (0.535 g, 0.7622 mmol) was added and the resulting reaction mixture, heated at 9O0C for 8 hrs, was worked up by addition of water and extraction with AcOEt. The organic phase, dried over anhydrous MgSO4, afforded upon evaporation a dark oily residue (-4.5 g), which was purified by preparative HPLC, to afford 1.21 O g (-26% yield) of the pure title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 39906-04-2, 4,6-Dichloro-2-methylpyrimidin-5-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NEUROSEARCH A/S; WO2009/112461; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia