Related Products of 876-21-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 876-21-1 as follows.
(3) Synthesis of 4-amino-5-chloromethyl-2-ethylpyrimidine hydrochloride 4.59 g (0.03 mol) of 4-amino-2-ethyl-5-(hydroxymethyl)-pyrimidine was charged into a 100 ml flask, followed by 20 ml of dichloromethane, 20 ml of toluene and 0.1 ml of pyridine. 6.5 ml of thionyl chloride (0.28 mol) was dropped in slowly with cooling by ice bath. Then the reaction was stirred overnight. Solvent was removed and the residue was used for next step directly. 1H-NMR (400M, d-DMSO): 8.45 (s, 1H), 4.80 (s, 2H), 3.64 (s, 2H), 2.80 (dd, 2H, J=7.6, 14.8), 1.24 (t, 3H, J=7.6).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,876-21-1, its application will become more common.
Reference:
Patent; GUANGZHOU ORIGMOL FEED-ADDITIVE CO., LTD; Peng, Xianfeng; Qin, Zonghua; Liu, Qijun; US9096581; (2015); B2;,
Pyrimidine | C4H4N2 – PubChem,
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