Electric Literature of 2227-98-7, Adding some certain compound to certain chemical reactions, such as: 2227-98-7, name is 4-Aminopyrrolo[3,2-d]pyrimidine,molecular formula is C6H6N4, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2227-98-7.
[0088] (2R)-2-[({4-Amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl}methyl)amino]-3- (pyrazin-2-ylsulfanyl)propan-l-ol (V.2). Compound V.l (0.220 g, 0.68 mmol) was dissolved in CH2CI2 (8 mL) and trifluoroacetic acid (2 mL) added. After 2 h the solvent was evaporated and the residue dissolved in MeOH (10 mL) and neutralized with Amberlyst A21 resin then passed through a short column of the same resin and eluted with MeOH. The fractions containing product were evaporated to a yellow gum that was dissolved in tert-butanol (4 mL) then aq. formaldehyde solution (37%, 0.061 mL, 0.81 mmol) and 9-deazaadenine (0.091 g, 0.68 mmol) were added and the mixture heated at 70 C for 16 h. Silica gel was added to absorb all the solvent then the solvent was evaporated and the residue chromatographed on silica gel (gradient of 10 – 15% 7M NH3/MeOH in CHCI3) to give V.2 as a colourless solid (0.055 g, 25%). XH NMR (500 MHz, CD3OD): delta 8.35 (d, J = 1.5 Hz, 1H), 8.28 (dd, J = 2.6, 1.7 Hz, 1H), 8.14 (d, J = 2.1 Hz, 1H), 8.12 (s, 1H), 7.43 (s, 1H), 4.05 (d, J = 13.9 Hz, 1H), 4.02 (d, J = 13.8 Hz, 1H), 3.74 (dd, J = 11.3, 4.9 Hz, 1H), 3.64 (dd, J = 11.3, 5.5 Hz, 1H), 3.39-3,31 (m, 2H + residual deuterated solvent), 3.01-2.97 (m, 1H). 13C NMR (125.7 MHz, CD3OD, centre line delta 49.0): delta 158.2 (C), 152.0 (C), 150.8 (CH), 146.5 (C), 145.2 (CH), 144.6 (CH), 140.3 (CH), 129.0 (CH), 115.4 (C), 114.7 (C), 63.7 (CH2), 58.4 (CH), 41.4 (CH2), 31.6 (CH2). ESI-HRMS calcd Ci4H18N7OS+ (M+H)+, 332.1289, found 332.1287.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 2227-98-7, 4-Aminopyrrolo[3,2-d]pyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY; SCHRAMM, Vern, L.; CLINCH, Keith; GULAB, Shivali, Ashwin; WO2015/123101; (2015); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia