With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.180869-36-7, name is 4-(Dimethoxymethyl)-2-(methylthio)pyrimidine, molecular formula is C8H12N2O2S, molecular weight is 200.26, as common compound, the synthetic route is as follows.Safety of 4-(Dimethoxymethyl)-2-(methylthio)pyrimidine
b 2-Methylthiopyrimidine-4-carboxaldehyde The product of example 1(a) (9.96 g, 50 mmol), and 3 N HCl (42 mL, 126 mmol) were combined and stirred at 48 C. for 16 h, cooled to 23 C., combined with EtOAc (200 mL) and made basic by the addition of solid Na2 CO3 (12.6 g, 150 mmol). The aqueous phase was extracted with EtOAc (4*150 mL, dried (Na2 DO4), concentrated and the residue was filtered through a pad of silica (ca 150 mL) with CH2 Cl2 to afford 7.49 g (97%) of the title compound 1 H NMR (CDCl3): delta 9.96 (s,1), 8.77 (d, 1), 7.44 (d, 1), 2.62 (s,3).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,180869-36-7, 4-(Dimethoxymethyl)-2-(methylthio)pyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; SmithKline Beecham Corporation; US6046208; (2000); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia