Synthetic Route of 3438-48-0 ,Some common heterocyclic compound, 3438-48-0, molecular formula is C10H8N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
The intermediate b (10 g, 0.06 mol)Was added to 500 mL of formamide,Stirred at room temperature for 30-60 minutes,After the intermediate b was completely dissolved,Transferred to the cold wells, the temperature control in 10 below,Dropping 20mL of concentrated sulfuric acid,While dropping hydrogen peroxide (50 mL)And aqueous ferrous sulfate heptahydrate solution (100 mL)Drop complete, 10-15 reaction 30min,After the reaction was completed, 2000 mL of water was added,Saturated sodium carbonate aqueous solution adjusted to pH 9,Dichloromethane was extracted three times (200 mL * 3)The combined dichloromethane was washed once with saturated brine,Dry methylene chloride as a white solid 5.7 g, yield 48%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3438-48-0, its application will become more common.
Reference:
Patent; Shenyang Pharmaceutical University; Gong, Ping; Zhao, Yanfang; Liu, Yaijing; Di, Xin; Tang, Qidong; (42 pag.)CN104072480; (2016); B;,
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