Synthetic Route of 10244-24-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 10244-24-3, name is 4,4′-(6-Chloropyrimidine-2,4-diyl)dimorpholine, molecular formula is C12H17ClN4O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: 2,4,6-trichlorotriazine (1.84 g, 0.01 mol)Soluble in anhydrous acetone (10 mL), ice-salt bath cooled to -10 C,Morpholine (1.74 mL, 0.02 mol)And triethylamine (2.02 g, 0.02 mol)Of the mixed liquid droplets added to the reaction system, 0 C reaction 3h, room temperature reaction 3h.The mixture was poured into crushed ice, filtered, washed with water and dried to give 2.70 g of a white solid, 94.4% yield
According to the analysis of related databases, 10244-24-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Xi’an Jiaotong University; YU, YAN; WANG, XIAO MENG; ZHANG, SAN QI; HU, SEN KE; LU, SHE MIN; MEI, QI BING; (10 pag.)CN104151256; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia