Synthetic Route of 4595-60-2 ,Some common heterocyclic compound, 4595-60-2, molecular formula is C4H3BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
The 1,10-phenanthroline 2,2,3,3-tetrafluoropropyl ether copper (I) prepared in Example 2,In a nitrogen atmosphere, a polytetrafluoroethylene magnet was placed in the reactor,Was added 0.36 mmol of 1,1,10-phenanthroline 2,2,3,3-tetrafluoropropyl ether copper (I) (phen) 2Cu (OCH2CF2CF2H)0.3 mmol of 2-bromopyrimidine,0.3 mmol of sodium tert-butoxide and 3 mL of N, N-dimethylformamide solvent,And stirred in a closed system at 80 C for 12 h, cooled to room temperature, extracted with 3 x 10 mL of ether,The extracts were combined and concentrated, and the resulting residue was subjected to silica gel column chromatography,With ether: n-pentane = 1: 1 as eluent,To give 2- (2,2,3,3-tetrafluoropropoxy) pyrimidine, yield = 94%
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4595-60-2, its application will become more common.
Reference:
Patent; Fuzhou University; Weng, Zhi Qiang; Huang, yangjie; Huang, ronglu; Ding, jianping; (9 pag.)CN104557924; (2016); B;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia