Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5177-27-5, name is 5-Amino-2,4-dichloropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 5-Amino-2,4-dichloropyrimidine
To a round-bottomed flask equipped with a magnetic stirrer was added 2,4-dichloropyrimidin-5-amine B (1.89 g, 11.52 mmol), DIPEA (8.05 mL, 46.1 mmol), morpholine-3-carboxylic acid A (1.66 g, 12.68 mmol), and DMSO (5 mL). The reaction was stirred at 100oC overnight. The mixture was poured into water and extracted with EtOAc for three times. The pH of the aqueous layer was adjusted (about 5) with 10 percent citric acid and extracted again with EtOAc. The combined organic layer was dried over MgSO4, filtered, and concentrated in vacuo to furnish a tan solid. The solid was triturated in diethyl ether containing a small amount of EtOH, filtered, and dried to give 2-chloro-6a,7,9,10-tetrahydro -[1,4]oxazino[3,4-h]pteridin -6(5H)-one C: 1.95 g (70.3% yield). MS [M+H] found 241.
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Reference:
Article; Jin, Stanley; Mikami, Satoshi; Scorah, Nick; Chen, Young; Halkowycz, Petro; Shi, Lihong; Kahana, Jason; Vincent, Patrick; de Jong, Ron; Atienza, Joy; Fabrey, Robyn; Zhang, Lilly; Lardy, Matthew; Bioorganic and Medicinal Chemistry Letters; vol. 29; 21; (2019);,
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