Application of 5413-85-4 ,Some common heterocyclic compound, 5413-85-4, molecular formula is C4H3Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A suspension of 4, 6-dichloropyrimidin-5-amine (12 g, 73 mmol) and N2H4-H2O (20 g, 402 mmol, 5.5 eq. ) in THF (30 mL) was stirred at rt for 50 hours. The mixture was poured into water and filtered. The filter cake was washed with water to give 4-chloro-6-hydrazinylpyrimidin-5-amine (9 g, 79yield) as a white solid. LC-MS: m/z 160.2 (M+H) +.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5413-85-4, 5-Amino-4,6-dichloropyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; TRAVINS, Jeremy, M.; KONTEATIS, Zenon, D.; SUI, Zhihua; YE, Zhixiong; (199 pag.)WO2018/39972; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia