Reference of 61727-33-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 61727-33-1, name is 5-Chloro-2-(methylthio)pyrimidine-4-carboxylic acid, molecular formula is C6H5ClN2O2S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Preparation Example 2: Preparation of 5-chloro-2-methanesulfonyl- pyrimidine-4-carboxylic acid methyl ester; Step 1) Preparation of 5-chloro-2-methylsulfanyl-pyrimidine-4-carboxylic acid methyl ester; 5-chloro-2-methylsulfanyl-pyrimidine-4-carboxylic acid (2.04 g, 10 mmol) was added to methanol, and 10 m? of thionyl chloride was slowly added thereto, followed by stirring the mixture for 5 hours. The resulting mixture was concentrated under a reduced pressure to remove the solvent, and sequentially washed with sodium bicarbonate solution and salt solution. The resulting residue was subjected to silica gel column chromatography (eluent: n- hexane/ethyl acetate=5:l) to obtain the title compound (2.1 g; yield: 95 %).
According to the analysis of related databases, 61727-33-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CRYSTALGENOMICS, INC.; WO2007/73117; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia