Reference of 51674-77-2, Adding some certain compound to certain chemical reactions, such as: 51674-77-2, name is 4-Chloropyrido[3,2-d]pyrimidine,molecular formula is C7H4ClN3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 51674-77-2.
5 Intermediate 22 (50 mg, 0.151 rnmol), 4-chloropyrido[3,2-d]pyrimidine (37.5 mg,0.226 mmol), DIPEA (0.079 niL, 0.453 rnmol) and M-BUOH (1 mL) were combined and heated under microwave irradiation at 140C for 1 h. After cooling, the mixture was dissolved in EtOAc (100 mL) and washed with saturated brine (3 x 20 mL). The organic layer was separated, dried (MgS04), filtered and concentrated in vacuo. Purification by10 preparative HPLC gave the title compound (3.7 mg, 5%) as a white solid. 6H (DMSO- ^) 8.82-8.77 (2H, m), 8.44 (1H, s), 8.41 (1H, s), 8.07 (1H, dd, J 8.46, 1.52 Hz), 7.80 (1H, dd, J 8.46, 4.25 Hz), 7.63 (1H, dd, J 8.92, 6.31 Hz), 7.22 (1H, t, J9.13 Hz), 5.96 (2H, s), 5.82-5.75 (1H, m), 3.57-3.45 (4H, m), 3.44-3.37 (2H, m), 3.04-2.96 (2H, m), 2.47 (3H, d, J2.24 Hz), 1.55 (3H, d, J 6.71 Hz). LCMS (ES+) 461 (M+H)+, RT 2.50 minutes {Method15 2).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 51674-77-2, 4-Chloropyrido[3,2-d]pyrimidine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; UCB PHARMA S.A.; ALLEN, Daniel, Rees; BUeRLI, Roland; HAUGHAN, Alan, Findlay; MATTEUCCI, Mizio; OWENS, Andrew, Pate; RAPHY, Gilles; SHARPE, Andrew; WO2011/58108; (2011); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia