These common heterocyclic compound, 52980-28-6, name is Ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: Ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate
General procedure: Oxoquinolines 9a-c(8 mmol) were reacted with the appropriate amine (8 mmol) in diphenyl ether(30 mL) at 210 C under magnetic stirring for 1 h. The resulting mixture was poured into petroleum ether. The obtained solid was filtered and recrystallized from dichloromethane/petroleum ether (1/1) to yield the derivatives listed below [28-30].
The synthetic route of Ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate has been constantly updated, and we look forward to future research findings.