Electric Literature of 5334-35-0 ,Some common heterocyclic compound, 5334-35-0, molecular formula is C6H5ClN4O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Example 109 l-methyl-6-(4-methylsulfonylpiperazin-l-yl)-5H-pyrazolo[3 4-d]pyrimidin-4-one (1-142) CASE 30893 step 2 The title compound was prepared by condensation (DIPEA/EtOH) of l-(methylsulfonyl)- piperazine (CASRN 55776-43-2) and Intermediate A: -NMR (400MHz, DMSO-i ) delta ppm 11.07 (s, 1H), 7.80 (s, 1H), 3.78-3.74 (m, 7H), 3.18 (t, J = 4.4 Hz, 4H), 2.91 (s, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5334-35-0, its application will become more common.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FENG, Jianwen; HAYNES, Nancy-Ellen; HERMANN, Johannes Cornelius; KIM, Kyungjin; LIU, Jin-Jun; SCOTT, Nathan Robert; YI, Lin; ZAK, Mark; ZHAO, Guiling; WO2013/182546; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
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