The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 54326-16-8, name is 5-Chloropyrimidin-2(1H)-one. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 5-Chloropyrimidin-2(1H)-one
EXAMPLE 3 1(4-Chlorophenylsulfinyl)methyl-5-chloropyrimidin-2-one Potassium tert-butoxide (4 mmol) in DMF (10 ml) was added to a solution of 5-chloropyrimidin-2-one (4 mmol) in DMF (40 ml). The mixture was stirred at room temperature for 10 min before 1-bromomethyl-sulfinyl-4-chlorobenzene (see Preparation 5) (4 mmol) was added. The resultant mixture was stirred at 60 C. for 2 days, the solvent distilled off at reduced pressure, the residue triturated with water, the insoluble material dried and washed with a little chloroform before recrystallization from DMSO; the crystalline material was also washed with a little methanol and finally with water; yield 0.30 g (25%), m.p. 262 C. (Found: C43.63; H2.68. Calc. for C11 H8 Cl2 N2 O2S: C43.59; H2.67) 1 H NMR (DMSO-d6); delta 5.12 (CH2), 7.60 (Ph, b.s.), 8.19 and 8.62 (H-4, H-6, d, J 4 Hz). IR (KBr): 1660 (CO), 1060 cm–1 (SO). MS (70 eV; m/e (rel. int. %): 302 (0.5, M), 159 (6), 145 (33), 143 (100).
With the rapid development of chemical substances, we look forward to future research findings about 54326-16-8.
Reference:
Patent; Nyegaard & Co. A.S.; US4596870; (1986); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia