Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5750-76-5, name is 2,4,5-Trichloropyrimidine. A new synthetic method of this compound is introduced below., 5750-76-5
General procedure: 2-Amino-N-methylbenzamide 10 was prepared according tothe general procedure in literatures 33-35. The prepared 2-amino-N-methylbenzamide 10 (1.00 g, 6.67 mmol) was added inone portion to 2,4,5-trichloropyrimidine (1.22 g, 6.67 mmol) or2,4-dichloro-5-nitropyrimidine (1.29 g, 6.67 mmol) and DIPEA(1.29 g, 10.0 mmol) in isopropanol (100 mL). The resulting mixturewas stirred at 85 C for 6 h. The mixture was evaporated to dryness,and the residue was recrystallised from MeCN/water 20:1to yield 2-(2-chloro-5-substitudedpyrimidin-4-ylamino)-Nmethylbenzamide(1.69 g, 85%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,5750-76-5, 2,4,5-Trichloropyrimidine, and friends who are interested can also refer to it.
Reference:
Article; Liu, He; Wu, Bin; Ge, Yang; Huang, Jiaxin; Song, Shijie; Wang, Changyuan; Yao, Jihong; Liu, Kexin; Li, Yanxia; Li, Yongming; Ma, Xiaodong; Bioorganic and Medicinal Chemistry; vol. 25; 24; (2017); p. 6313 – 6321;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia