As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 58536-46-2, name is 4-(4-Bromophenyl)-2,6-diphenylpyrimidine, molecular formula is C22H15BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C22H15BrN2
F-4 8.0g (23.23mmol), 4- (4- bromophenyl) pyridine-2,6-diphenyl (4- (4-bromophenyl) -2,6-diphenylpyrimidine), 9.9g (25.55mmol), Pd2 (dba) 3 2.1g (2.323mmol), P (t-Bu) 3 0.22g (2.323mmol), sodium tert-butoxide 14.1g (69.69mmol) and stirred for 6 hours under the reflux of toluene in 120C 150mL. After cooled back to room temperature after completion of the reaction the solid is created filter was washed with ethyl acetate (EA), methanol (MeOH). Then after the solid boiled with excess Toluene filter to obtain the title compound 1-482 10.8g (71%).
With the rapid development of chemical substances, we look forward to future research findings about 58536-46-2.
Reference:
Patent; HEESUNG MATERIAL LTD.; LEE, JEONG HYEON; JONG, SOO JIN; KIM, KI YOUNG; KIM, DONG JOON; PARK, CHAN JOON; CHOI, JIN SEOK; CHOI, DAE HYEOK; EUM, SONG JIN; LEE, JOO DONG; (164 pag.)KR101579289; (2015); B1;,
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