Related Products of 124703-78-2 , The common heterocyclic compound, 124703-78-2, name is 6-Ethylpyrimidin-4(3H)-one, molecular formula is C6H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
(ii) 4,5-Dichloro-6-ethylpyrimidine To a solution of 6-ethylpyrimidin-4(3H)-one (the product of part (i)) (18.6 g, 150 mmol) in concentrated hydrochloric acid (120 ml) at 30-40 C. was added dropwise a 30 wt. % solution of hydrogen peroxide in water (18 ml) over a period of 30 minutes (slight exotherm resulted) and the resulting mixture was stirred overnight at 40 C. The mixture was concentrated under reduced pressure and the residue was suspended/dissolved in toluene and the toluene removed under reduced pressure. The residue was dissolved in phosphorus oxychloride (150 ml) and heated under reflux for 3 hours after which time the excess phosphorus oxychloride was removed under reduced pressure. The residue was poured into ice/water, extracted with methylene chloride (3*50 ml) and the combined organic extracts were washed with water (30 ml) and dried over magnesium sulphate. The solvent was removed under reduced pressure and the resulting oil was distilled under reduced pressure to yield the title compound (5.4 g, 20%), b.p. 104 C. at 22 mm Hg, which was characterised by 1 H-NMR spectroscopy. 1 H-NMR (CDCl3): delta=1.3 (t, 3H, J=10Hz), 3.04 (q, 2H, J=10Hz), 8.75 (s, 1H), ppm.
The synthetic route of 124703-78-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Pfizer Inc.; US5278175; (1994); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia