Adding a certain compound to certain chemical reactions, such as: 30129-57-8, 6-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4(7H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyrimidines, blongs to pyrimidines compound. category: pyrimidines
Example 63A 4-Chloro-6-methyl-1H-pyrazolo[3,4-d]pyrimidine This compound was prepared according to a modified specification from: C. C. Cheng, R. K. Robins, J. Org. Chem. 1958, 23, 191. 4.878 g (33.2 mmol) of 6-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-ol (J. Org. Chem. 1958, 23, 191) was put in 50 ml toluene, 15.5 ml (165.8 mmol) of phosphoryl chloride and 12.7 ml (72.9 mmol) of diisopropyl ethylamine were added and it was stirred for 1 h at 80 C. It was concentrated by evaporation and distributed between ethyl acetate and 1 M hydrochloric acid. The organic phase was dried over sodium sulphate and concentrated by evaporation. The residue (4.464 g, 92% purity, 73% of theor.) was processed further without purification. LC-MS (method 1): Rt=0.53 min; MS (ESIpos): m/z=169 (M+H)+
The synthetic route of 30129-57-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER INTELLECTUAL PROPERTY GMBH; FOLLMANN, Markus; STASCH, Johannes-Peter; REDLICH, Gorden; GRIEBENOW, Nils; LANG, Dieter; WUNDER, Frank; HUeBSCH, Walter; LINDNER, Niels; VAKALOPOULOS, Alexandros; TERSTEEGEN, Adrian; US2013/338137; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia