With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.65754-04-3, name is 6-Oxo-1,6-dihydropyrimidine-5-carboxylic acid, molecular formula is C5H4N2O3, molecular weight is 140.1, as common compound, the synthetic route is as follows.name: 6-Oxo-1,6-dihydropyrimidine-5-carboxylic acid
A mixture of 4-hydroxy-5-pyrimidinecarboxylic acid (0.88 g, 6.3 mmol) in 5 drops of DMF and 6 mL of thionyl chloride was heated at reflux for 3 hours. The mixture was concentrated and the residue was dissolved in methylene chloride. A mixture of the residue, dimethylamine hydrochloride (0.62 g, 7.6 mmol) and triethylamine (4.5 mL, 31.5 mmol) in 50 mL of methylene chloride was stirred at 0 C. for 0.5 hours. The mixture was poured into water and aqueous sodium bicarbonate. The mixture was extracted with methylene chloride (2*30 mL) and the extract was washed with brine, dried (Na2 SO4) and concentrated by rotary evaporation to give 4-chloro-N,N-dimethyl-5-pyrimidinecarboxamide (0.66 g, 3.6 mmol) as an oil.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,65754-04-3, 6-Oxo-1,6-dihydropyrimidine-5-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; Syntex (U.S.A.) Inc.; US5688795; (1997); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia