With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.60703-46-0, name is 2,4,6-Trichloro-5-methoxypyrimidine, molecular formula is C5H3Cl3N2O, molecular weight is 213.4491, as common compound, the synthetic route is as follows.Computed Properties of C5H3Cl3N2O
Step 3: Under an atmosphere of nitrogen a solution of 2,4,6-trichloro-5-methoxy- pyrimidine (4.0 g, 18.7 mmol) in DCM (200 mL) was cooled to 0C and treated with boron tribromide (neat, 6.6 mL, 65 mmol) dropwise. After stirring for 18 hours at room temperature LCMS analysis indicated complete reaction. The reaction mixture was cooled and carefully diluted with methanol (25 mL) and the reaction mixture diluted with water (200 mL). The aqueous layer was washed with DCM and the combined organic extracts dried (Na2S04) filtered and concentrated in vacuo to give 2,4,6-trichloro-5-hydroxy-pyrimidine as a pale tan solid (2.55 g, 71%). 13C NMR (DMSO-de): 149.23 (C), 145.25 (C), 145.08 (C). LCMS: RT= 2.65/2.77 [M- H]-= 197/199.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,60703-46-0, 2,4,6-Trichloro-5-methoxypyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; F. HOFFMANN-LA-ROCHE AG; DOTSON, Jennafer; HEALD, Robert Andrew; HEFFRON, Timothy; JONES, Graham Elgin; KRINTEL, Sussie Lerche; MCLEAN, Neville James; NDUBAKU, Chudi; OLIVERO, Alan G.; SALPHATI, Laurent; WANG, Lan; WEI, BinQing; WO2012/82997; (2012); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia