Synthetic Route of 63155-43-1, Adding some certain compound to certain chemical reactions, such as: 63155-43-1, name is 2-(4,6-Dichloropyrimidin-2-yl)acetonitrile,molecular formula is C6H3Cl2N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 63155-43-1.
To a solution of 2-(4,6-dichloropyrimidin-2-yl)acetonitrile (2.2 g, 11.7 mmol) and triethylamine (3.0 mL, 20.8 mmol) in ethyl acetate / MeOH (1/1, 40 mL) was added 10% Pd/C (400 mg) and the solution was vigorously stirred for 2.5 hours under H2 atmosphere (1 atm). The reaction was filtered through celite and washed the celite with MeOH. The combined filtrates were concentrated under reduced pressure and purified by flash chromatography (5i02, PE / EA = 1/1) to give the 2-(pyrimidin-2-yl)acetonitrile as a pale red liquid (618 mg, 54%). MS [MH] calcd for C6H5N3 120.1, found 120.1.
According to the analysis of related databases, 63155-43-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING; HUANG, Niu; PENG, Shiming; (87 pag.)WO2016/206573; (2016); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia