Synthetic Route of 63200-54-4, Adding some certain compound to certain chemical reactions, such as: 63200-54-4, name is 2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine,molecular formula is C6H3Cl2N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 63200-54-4.
2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine (376 mg, 2 mmol), 13 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (832 mg, 4 mmol), anhydrous 14 copper acetate (363 mg, 2 mmol), and 15 pyridine (158 mg, 2 mmol) were added into 16 dimethylsulfoxide (10 mL). The reaction liquid was heated to 110 C and stirred overnight. The reaction liquid was naturally cooled down to room temperature, followed by adding 17 ethyl acetate (50 mL). The insolubles were removed by filtration. The filtrate was washed with water (40 mL × 2), dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was beaten in a mixed solution of 18 n-hexane / ethyl acetate (2/1, 30 mL), and filtered to give 150 mg of a pale yellow solid. Yield: 28.0%. MS (ESI, m/z): [M+H]+: 267.9.
According to the analysis of related databases, 63200-54-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Beijing Hanmi Pharmaceutical Co., Ltd.; XU, Jiangcheng; CAI, Qingyuan; CHA, Mi Young; KIM, Maengsup; (85 pag.)EP3336090; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia