672-41-3 ,Some common heterocyclic compound, 672-41-3, molecular formula is C5H4F3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of 6-(trifluoromethyl) pyrimidin-4- amine (1.0 g, 6.2 mmol) in DMF (30 mE) was added NBS (1.2 g, 6.8 mmol). The mixture was heated to 70 C. for 1 hout The reaction mixture was cooled to it, diluted with H20, and extracted with EtOAc (x2). The combined organic extracts were washed with brine; dried (Na2504) and concentrated in vacuo. The crude product was triturated in DCM to obtain title compound as white solid (1.38 g, 93%).
According to the analysis of related databases, 672-41-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Janssen Pharmaceutica NV; Ameriks, Michael K.; Laforteza, Brian Ngo; Lebold, Terry Patrick; Ravula, Suchitra; Savall, Brad M.; Shireman, Brock T.; (70 pag.)US2018/111942; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia