With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7752-78-5, name is 5-Bromo-2-methylpyrimidine, molecular formula is C5H5BrN2, molecular weight is 173.01, as common compound, the synthetic route is as follows.Computed Properties of C5H5BrN2
Preparation 14: 2-methyl-5-[1-(phenylmethyl)-2,5-dihydro-1W-pyrrol-3-yl]pyrimidine (P14)The title compound can be prepared through a coupling palladium mediated reaction, e.g. starting from 5-bromo-2-methylpyrimidine and 1-(phenylmethyl)-3-(4,4,5,5-tetramethyl- 1 ,3,2-dioxaborolan-2-yl)-2,5-dihydro-1H-pyrrole. For example, to a solution of 5-bromo-2- methylpyrimidine (1.3 eq.) in THF, 1-(phenylmethyl)-3-(4,4,5,5-tetramethyl-1 ,3,2- dioxaborolan-2-yl)-2,5-dihydro-1H-pyrrole (1 eq.), tetrakis(triphenylphosphine)palladium(0) (5percent mol) and cesium fluoride (4 eq.) may be added at room temperature. The resulting mixture should be stirred at 80 0C for 1.5 hours. After cooling the solvent should be evaporated under reduced pressure and the residue partitioned between dichloromethane and sodium hydroxyde (1 M). The organic phase should be evaporated under reduced pressure and the crude product purified by flash chromatography to give the title compound.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,7752-78-5, 5-Bromo-2-methylpyrimidine, and friends who are interested can also refer to it.
Reference:
Patent; GLAXO GROUP LIMITED; WO2007/22933; (2007); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia