Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 831203-15-7, name is 2-(5-Bromopyrimidin-2-yl)acetonitrile. This compound has unique chemical properties. The synthetic route is as follows. name: 2-(5-Bromopyrimidin-2-yl)acetonitrile
At room temperature, under a nitrogen atmosphere,(5-bromopyrimidin-2-yl) acetonitrile (150 mg, 0.76 mmol),1-octyne (167 mg, 1.51 mmol),PdCl2 (13 mg, 0.08 mmol),Triphenylphosphine (40 mg, 0.15 mmol),CuI (7 mg, 0.04 mmol),Triethylamine (0.81 ml) and THF (1.8 ml) were added and the mixture was stirred at 40 C. for 3 hours.Thereafter, filtration with celite was carried out, and the filtrate was concentrated under reduced pressure to obtain a crude product. The obtained crude product was purified using thin layer column chromatography (hexane: ethyl acetate = 2: 1) to obtain [5- (1-octynyl) pyrimidin-2-yl] acetonitrile. Yield 138 mg, yield 80%, yellow liquid.
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Reference:
Patent; NIPPON STEEL & SUMIKIN CHEMICAL COMPANY LIMITED; KYUSHU INSTITUTE OF TECHNOLOGY; NAGAHAMA, TAKUO; KAWADA, ATSUSHI; TAKASHIMA, WATARU; OKAUCHI, TATSUO; NAGAMATSU, SHUICHI; (69 pag.)JP2017/178911; (2017); A;,
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