Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 89283-48-7, name is 4-Chloro-6-(methylthio)pyrimidine. A new synthetic method of this compound is introduced below., Recommanded Product: 4-Chloro-6-(methylthio)pyrimidine
mCPBA (5.6 g, 32.6 mmol) was added to a stirred mixture of 4-chloro-6- (methylthio)pyrimidine (3.5 g, 21.7 mmol) in DCM (100 mL). The resulting mixture was stirred for 1 hour at rt, quenched by the addition of aqueous NaHCCh (10%, 100 mL), and extracted with DCM (3 x 50 mL). The combined organic layers were washed with brine (50 mL), dried over anhydrous NaiSCL, filtered, and concentrated under vacuum. The residue was purified by column chromatograph (EA in PE from 0% to 20%) to afford 4-chloro-6- (methylsulfmyl)pyrimidine (2.8 g, 73% yield) as a yellow solid. LCMS (m/z) 177 (M+H)+, retention time: 0.345 min, LC/MS Method 20.
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Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; FOX, Ryan Michael; HARRIS, Philip Anthony; HOLENZ, Joerg; SEEFELD, Mark Andrew; ZHOU, Ding; (119 pag.)WO2019/130230; (2019); A1;,
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