Related Products of 90914-41-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 90914-41-3, name is 3-Bromo-4-chloro-1H-pyrazolo[3,4-d]pyrimidine, molecular formula is C5H2BrClN4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of N-Boc-4-(p-chlorophenyl)-piperidine-4-carbamide (135 mg, 0.40 mmol) in DMF (4 mL) was added NaH (60% in mineral oil, 20 mg, 0.5 mmol). The stirring was continued for 30 min. Then 3-(diethylamino)propyl chloride (90 mg, 0.60) was added. The mixture was then warmed to 90 0C. The stirring was continued for another 3 h. To the cooled mixture was added H2O. It was then extracted with EtOAc. The organic phase was washed with brine, and dried over Na2SO4. Removal of EtOAc gave the crude product. The crude product (about 0.4 mmol) obtained above was treated with excess TFA in DCM for 30 min. Upon removal of excess TFA and DCM, the residue was free-based and then reacted with 3-Bromo-4-chloro-lH-pyrazolo[3,4-d]pyrimidine (40 mg, 0.17 mmol) in the presence of Et3N (152 mg, 1.5 mmol) in 1,4-dioxane (2 mL) at 70 0C for 1 h. The mixture was concentrated. The crude product was purified by preparation EtaPLC. LC-MS (M+l): 550.4 (100%), 548.4 (80%).1H NMR (400 MHz, DMSO-d6) delta 8.31 (s, 1 H), 7.83 (t, J = 5.5 Hz, 1 H), 7.41 (s, 4 H), 4.25 (br d, J = 13.4 Hz, 2 H), 3.37 (br t, J = 11.9 Hz, 2 H), 3.08 (q, J = 6.4 Hz, 2 H), 2.63 (br d, J = 13.7 Hz, 2 H), 2.34 (q, J = 7.2 Hz, 4 H), 2.23-2.19 (m, 2 H), 1.99-1.92 (m, 2 H), 1.49-1.41 (m, 2 H), 0.85 (t, J = 7.2 Hz, 6 H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 90914-41-3, 3-Bromo-4-chloro-1H-pyrazolo[3,4-d]pyrimidine.
Reference:
Patent; EXELIXIS, INC.; WO2006/71819; (2006); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia