Application of 934524-10-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 934524-10-4 as follows.
A stirred solution of S-2 (5.00 g, 14.6 mmol) in EtOH (50 mL) taken in a round- bottom flask was charged with DIPEA (5.0 mL, 29.2 mmol) and S-11 (1.74 g, 20.5 mmol) at room temperature. The reaction mixture was heated to 80C for 5 h under nitrogen atmosphere and was concentrated under reduced pressure. The crude residue was purified by column chromatography on silica gel using 0- 50% EtOAc in hexanes as eluent to afford S- 12 (3.80 g, 65%, AMRI lot IN-SKY-C-11) as an off-white solid. The compound was characterized by 1H NMR analysis.1H NMR (400 MHz, CDCl3): delta 8.08 (d, J = 8.36 Hz, 2H), 7.39 (d, J = 4 Hz, 1H), 7.30 (d, J = 8.12 Hz, 2H), 6.43 (d, J = 4 Hz, 1H), 5.25 (d, J = 7.48 Hz, 1H), 3.7 (q, J = 14.44 Hz, 1H), 2.39 (s, 3H), 1.28 (d, J = 6.52 Hz, 3H), 0.91- 0.87 (m, 1H), 0.56- 0.41 (m, 2H), 0.39- 0.24 (m, 2H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,934524-10-4, its application will become more common.
Reference:
Patent; SOUTHERN RESEARCH INSTITUTE; AUGELLI-SZAFRAN, Corinne, E.; SUTO, Mark; GALEMMO, Robert; MOUKHA-CHAFIQ, Omar; GUPTA, Vandana; ANANTHAN, Subramaniam; (254 pag.)WO2017/106771; (2017); A1;,
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