Reference of 289042-12-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 289042-12-2, name is tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate, molecular formula is C29H40FN3O6S, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of compound IV (wherein X=0 and R2=tert-butyl; 100 gms) in acetonitrile (700 mL) at 35C to 40C was added 0.05M aqueous HCl solution (300 mL). Stirred the reaction mass at 35C to 40C until reaction completion and cooled to 0C to 5C. Added 1.0 M aqueous sodium hydroxide solution (300 mL), temperature was raised to 25 C to 35C and stirred until reaction completion. Cooled the reaction mass to 0C to 5C, pH was adjusted to 3.4 to 4.0 with 1M aqueous HCl solution (300 mL) and extracted with ethyl acetate. Washed the organic layer with 10% aqueous sodium chloride solution and concentrated under vacuum. Charged ethyl acetate (800 mL) to the obtained residue followed by cyclohexane- 1,2-diamine (29.5 gms) over a period of 15-30 min. The reaction mass was stirred at 25C to 35C for 60 mins, cooled to 0C to 5C and stirred for 2 hrs. The precipitated product was filtered and dried to obtain 80 gms of rosuvastatin cyclohexane- 1,2-diamine salt as white solid. HPLC Purity: >99% The XRPD is set forth in Figure 1.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 289042-12-2, tert-Butyl 2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate.
Reference:
Patent; LAURUS LABS PRIVATE LIMITED; BOLLU, Ravindra Babu; MANDADAPU, Venkata Pramod Kumar; INDUKURI, Venkata Sunil Kumar; GORANTLA, Seeta Rama Anjaneyulu; CHAVA, Satyanarayana; (48 pag.)WO2016/125086; (2016); A1;,
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