Adding a certain compound to certain chemical reactions, such as: 14080-56-9, Thieno[2,3-d]pyrimidin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 14080-56-9, blongs to pyrimidines compound. Quality Control of Thieno[2,3-d]pyrimidin-4-amine
To a solution of 100 mg (253 pmol) 6-bromo-4-hydroxy-8-methyl-4-(trifluoromethyl)-2H-spiro[cyclohexane-1 ,3-imidazo[1 ,5-a]pyridine]-1 ,5-dione (prepared according to example127a) and 42 mg (278 pmol) thieno[2,3-d]pyrimidin-4-amine (GAS-No.: 14080-56-9) in 8.2 mL 1 ,4-dioxane was added 247 mg cesium carbonate and the mixture was degassed and purged with argon several times. 15.7 mg 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene, 12.9 mg 2-(dicyclohexyl-phosphino)-2,4,6-triisopropylbiphenyl, 6.1 mg palladium(ll)acetateand 24.8 mg tris(dibenzylideneacetone)dipalladium(0) were added and the mixture was stirred at 1000 for 2 hours. After concentration t he residue was purified by flash chromatography (Biotage SNAP cartridge silica 25 g, methanol: dichloromethane) and crystallization from methanol to give 42 mg (32%) of the title compound. LC-MS: m/z = 466.2 [M÷H].1HNMR (400 MHz, DMSO-d6), 6 [ppm]= 1.43 (2H), 1.83 (2H), 1.96 (2H), 2.52 (3H*), 3.46(2H), 5.99 (1H), 7.82 (1H), 7.87 (1H), 8.65 (1H), 8.70 (1H), 9.07 (1H), 10.43 (1H);*: at least partially hidden by solvent or water signal
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,14080-56-9, its application will become more common.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BAYER AKTIENGESELLSCHAFT; KLAR, Ulrich; BOHLMANN, Rolf; SCHAeCKE, Heike; SUeLZLE, Detlev; MENZ, Stephan; PANKNIN, Olaf; (249 pag.)WO2018/134148; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia