Pinkerton, Anthony B.; Peddibhotla, Satyamaheshwar; Yamamoto, Fusayo; Slosky, Lauren M.; Bai, Yushi; Maloney, Patrick; Hershberger, Paul; Hedrick, Michael P.; Falter, Bekhi; Ardecky, Robert J.; Smith, Layton H.; Chung, Thomas D. Y.; Jackson, Michael R.; Caron, Marc G.; Barak, Lawrence S. published an article about the compound: (S)-3-Methoxypyrrolidine( cas:120099-61-8,SMILESS:CO[C@@H]1CNCC1 ).COA of Formula: C5H11NO. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:120099-61-8) through the article.
Neurotensin receptor 1 (NTR1) is a G protein coupled receptor that is widely expressed throughout the central nervous system where it acts as a neuromodulator. Neurotensin receptors have been implicated in a wide variety of CNS disorders but despite extensive efforts to develop small mol. ligands there are few reports of such compounds Herein we describe the optimization of a quinazoline based lead to give 18 (SBI-553(I)), a potent and brain penetrant NTR1 allosteric modulator.
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Reference:
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia