Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10320-42-0, name is 2-Chloro-5-nitropyrimidine. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 10320-42-0
A dry 50 mL reaction jar was vacuumed three times with nitrogen, and then aniline (107 mg, 1.0 mmol, 1.0 equiv) was added to the reaction flask.Add 10.0 mL of dried acetonitrile and stir until the toluidine is fully dissolved.Then 2-chloro-5-nitropyrimidine (0.1593 g, 1.0 mmol, 1.0 equiv) was added to the reaction flask.All mixtures react under nitrogen pressure for 4-5 hours. The reaction detects the progress of the reaction by TLC.The reaction can be stopped if it is detected that all the aniline is completely reacted.The experimental treatment is to drain the solution in the reaction;The solute in the reaction flask was dissolved with ethyl acetate.And transferred to a 100 mL round bottom flask,Add 2 mL (200-300 mesh) of silica gel to the round bottom flask for spin-drying.(petroleum ether and ethyl acetate) over silica gel in column. Wait until the intermediate product is pale yellow crystal5-nitro-N-(m-tolyl)pyrimidin-2-amine(209 mg, 97% yield).
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Reference:
Patent; Jinan University; Feng Pengju; Chen Tianfeng; Chen Junfeng; Huang Yifeng; (25 pag.)CN108148005; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia