Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 106157-82-8, name is 1-(2-Aminopyrimidin-4-yl)ethanone. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 1-(2-Aminopyrimidin-4-yl)ethanone
Step C: Preparation of tert-Butyl [7- {2- [L- (2-AMINO-] [PYRIMIDIN-4-YL)-ETHYLAMINO]-BENZOYLAMINO}-4,] 4-dimethyl-3,4- [DIHYDRO-LH-ISOQUINOLINE-2-CARBOXYLATE] To a solution of [1-(2-AMINO-PYRIMIDIN-4-YL)-ETHANONE] (Step B, 200 mg, 1.46 mmol) in toluene (15 mL) was added, 7- [(2-AMINO-BENZOYLAMINO)-4,] 4-dimethyl-3, [4-DIHYDRO-LH-] isoquinoline-2-carboxylic acid tert-butyl ester (Example 15, Step A) (288 mg, 0.73 mmol), and HOAc (3 drops). The resulting mixture was heated at [95 C] under N2 for 20 h. The reaction was cooled to RT and NaBH (OAc) 3 (620 mg, 2.92 mmol) was added and reheated for 3 h. The reaction was cooled to RT, quenched with [NA2CO3] solution (2 M, 5 mL), solvent was evaporated in vacuo. The residue was extracted with CHC13. The organic layer was washed with saturated [NAHC03,] water, brine, dried over [MGS04,] and evaporated in vacuo. The crude solid was purified by chromatography on silica gel. Elution with [CH2CL2 : MEOH] (95: 5) gave THE final compound. MS [M/Z] : 517.3 (M+H). [CALC’D.] for [C2GH37N603-] 517.63.
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Reference:
Patent; AMGEN INC.; WO2004/5279; (2004); A2;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia