Application of 1100318-96-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1100318-96-4, name is 4-Iodo-7H-pyrrolo[2,3-d]pyrimidine, molecular formula is C6H4IN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
[00304] 206 mg (0.84 mmol) of 4-iodo-7H-pyrrolo[2,3-d]pyrimidine was dissolved in 1 ml_ DMF. 37 mg (0.92 mmol) of 60% sodium hydride was added followed by 58 mul_ (0.92 mmol) of iodomethane. The reaction was quenched by adding 10 ml_ of water, the solid filtered off, washed with 10 ml_ of water, then 10 ml_ of hexanes and dried. Yield: 142 mg of a tan powder, 90% pure.
According to the analysis of related databases, 1100318-96-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CHEMOCENTRYX, INC.; WO2009/9740; (2009); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia