Synthetic Route of 111196-81-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 111196-81-7 as follows.
Step 1: l-(5-ethylpyrimidin-2-yl)piperidin To a solution of piperidin-4-ol (2.55 g, 25.2 mmol) in MeCN (50 mL) was added 2-chloro-5-ethylpyrimidine (3.00 g, 21.0 mmol), followed by N-ethyl-N-isopropylpropan-2-amine (7 mL, 42.0 mmol) and the resulting reaction mixture was heated to 80C for 16 hrs. The mixture was diluted with water, extracted with EtOAc, washed with brine, dried over Na2S04, filtered and concentrated in vacuo. The residue was purified with column chromatography (CH2C12: EtOAc = 3:1 to 1:1) to afford the desired product (3.69 g, 85%) as a yellow solid.1H NMR (CDC13): delta 8.16 (2H, s), 4.37-4.42 (2H, m), 3.92-3.94 (1H, m), 3.24-3.30 (2H, m), 2.45 (2H, q, / = 7.6 Hz), 1.92-1.98(2H, m), 1.69 (1H, brs), 1.48-1.53 (2H, m), 1.19 (3H, t, / = 7.6 Hz).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,111196-81-7, its application will become more common.
Reference:
Patent; CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; ZHU, Yan; HU, Yuandong; WANG, Huting; LIU, Yuliang; LI, Jijun; SUN, Deguang; WANG, Zhe; WEI, Yongheng; WANG, Zanping; TANG, Guojing; JING, Lutao; WO2012/103806; (2012); A1;,
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