Reference of 1122-47-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1122-47-0, name is 4-Amino-1-methylpyrimidin-2(1H)-one. A new synthetic method of this compound is introduced below.
To a water solution (5 mL) of 1-Methylcytosine (1-Mecyt) (0.025 g, 0.2 mmol) was added dropwise and under stirring, an aqueous solution of BaCl2·2H2O (0.049 g, 0.2 mmol) at 60 C.The colorless mixture was left to evaporate and afforded colorless crystals within 2-3 days, upon very slow evaporation at room temperature. Yield: 65%; IR (KBr, nu/cm-1): 3421, 3326,3245, 3155 (O-H), 2911 (C-H), 1665, 1632, 1630, 1570 (C=O). Anal. Calcd for C5H9N3O2Cl2Ba(350.91 g mol-1): C, 17.09; H, 2.58; N, 11.96%. Found C, 17.89; H, 2.92; N, 10.99%. Compound 2 was prepared following the same synthetic protocol as for 1 using an aqueous solution(5 mL) of BaBr2·2H2O (0.067 g, 0.2 mmol). Yield: 65%; IR (KBr, nu/cm-1): 3420, 3321, 3236, 3149(O-H), 2907 (C-H), 1670, 1639, 1622, 1569 (C=O). Anal. Calcd for C5H9N3O2Br2Ba (440.28 gmol-1): C, 13.64; H, 2.06; N, 9.54%. Found C, 13.24; H, 2.50; N, 9.05%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1122-47-0, 4-Amino-1-methylpyrimidin-2(1H)-one, and friends who are interested can also refer to it.
Reference:
Article; Marino, Nadia; Bruno, Rosaria; Armentano, Donatella; De Munno, Giovanni; Journal of Coordination Chemistry; vol. 71; 6; (2018); p. 828 – 844;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia