In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 145783-15-9, name is 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine, the common compound, a new synthetic route is introduced below. Recommanded Product: 145783-15-9
Vc (63.29 g, 0.21 mol) was added to 500 mL of absolute ethanol.VI (50.00 g, 0.21 mol) and triethylamine (63.63 g, 0.63 mol) were added.The reaction is sealed, protected by nitrogen, and heated to 100-130 C.The reaction is carried out for 25 to 30 hours, the temperature is lowered, and the solvent is distilled off under reduced pressure.Add 300 mL of ethyl acetate and 300 mL of water.The pH of the solution was adjusted to 5 with 3M hydrochloric acid to separate the organic phase.It was dried over anhydrous sodium sulfate for 2 hours, and concentrated under reduced pressure to half.Add 400 mL of isooctane, stir and crystallize at 15 C for 10 hours, and filter.Collect solids and dry to give compound IVc92.96 g, yield 88%.
The synthetic route of 145783-15-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Tianfang Pharmaceutical Co., Ltd.; Fan Zhen; Ma Junxia; Zhou Xinjian; Wang Junchen; Ren Zhen; Ma Qi; Wang Hui; Wu Xiangyong; Zhang Xiangfei; Zhao Zhen; Ma Zhenzhen; (12 pag.)CN108690026; (2018); A;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia