1780-26-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1780-26-3 as follows.
Into clean and dry 5.0 L 4-neck RB flask charged 2-amino-N-(2-chloro-6-methyl (0125) phenyl)-5-thiazole-l-carboxamide (200gm), 4,6-dichloro-2-methyl (0126) pyrimidine(146 g), 2.0 L of THF under nitrogen atmosphere. Clear solution (0127) formation was observed, cooled the reaction mass to temperature 10-20C, added (0128) 30% sodium -t-butoxide (845gm) solution to the reaction mass over a period of 60- (0129) 75min at temperature 10-20C. Brown coloured solution formation was observed. (0130) Reaction mass temperature was raised to 25-30C and maintained the reaction (0131) mass temperature to 25-30C for 90-120 min, cooled the mass to temperature 0- (0132) 5C and added 2N HCl solution to the reaction mass over a period of 60-90min at 0-5C and maintained for 105-120min. Transferred the reaction mass into a buchner funnel and flask kept under plant vacuum. Washed the wet cake with 600.0mlof water.Suck dried thoroughly for 45-60 mi and dried the wet material in a drier at temperature 60-65 C for 8-10hrs. (0133) Weight: 210 gm
The chemical industry reduces the impact on the environment during synthesis 1780-26-3, I believe this compound will play a more active role in future production and life.
Reference:
Patent; NATCO PHARMA LIMITED; KONAKANCHI, Durga Prasad; GONGALLA, Buchappa; KOTRA, Uma Naresh Babu; SAKKANI, Srinivasulu; RAGIDI, Dharmender; SIKHA, Kotayyababu; NANNAPANENI, Venkaiah Chowdary; (18 pag.)WO2018/100585; (2018); A1;,
Pyrimidine | C4H4N2 – PubChem,
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