Some tips on 2-bromo-5-fluoropyrimidine

According to the analysis of related databases, 947533-45-1, the application of this compound in the production field has become more and more popular.

Related Products of 947533-45-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 947533-45-1, name is 2-bromo-5-fluoropyrimidine. This compound has unique chemical properties. The synthetic route is as follows.

3-Methyl-1 ,3-butanediol (180 mg is stirred in 5 mL of Nu,Nu-dimethylformamide at 0 C, sodium hydride (6 mg of a 60% mineral oil suspension) is added and the reaction mixture is stirred for 2 h, then it is added dropwise to a solution of 2-bromo-4-fluoro- pyrimidine (300 mg) in 5 mL of N,N- dimethylformamide and the reaction mixture stirred at 0 C for 2 h again. The solvent is removed and the residue is purified by flash chromatography (hexane/ethyl acetate 90:10?70:30) to g i ve th e t it l e compound. Yield: 20 mg.

According to the analysis of related databases, 947533-45-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ECKHARDT, Matthias; FRATTINI, Sara; HAMPRECHT, Dieter; HIMMELSBACH, Frank; LANGKOPF, Elke; LINGARD, Iain; PETERS, Stefan; WAGNER, Holger; WO2013/144098; (2013); A1;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia