Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1245506-61-9, name is 2-Chloro-5-methoxy-4-methylpyrimidine. A new synthetic method of this compound is introduced below., Product Details of 1245506-61-9
General procedure: To a solution of 2-methoxy-5-methylpyridin-3-yl acetate (5.80 g, 32.0 mmol) in anhydrous CH2Cl2 (50 mL) was added with N-bromosuccinimide (5.69 g, 32.0 mmol) and AIBN (530 mg, 3.23 mmol). The reaction mixture was heated at reflux for 24 h, added with N-bromosuccinimide (1.14 g, 6.41 mmol), further heated at reflux for 18 h, and concentrated under reduced pressure. The residue was purified by flash column chromatography (silica gel, hexane ramping to CH2Cl2:hexane = 1:1) to give 9 as a colourless liquid (3.88 g, 47%).
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Reference:
Article; Long, Yi; Yu, Mingfeng; Li, Peng; Islam, Saiful; Goh, Aik Wye; Kumarasiri, Malika; Wang, Shudong; Bioorganic and Medicinal Chemistry Letters; vol. 26; 23; (2016); p. 5674 – 5678;,
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