Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 66131-68-8, name is 2-Chloro-N-methylpyrimidin-4-amine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 66131-68-8
Into a 100-mL round-bottom flask, was placed 4-methoxy-3-[(l- methylpyrrolidin-3-yl)methoxy]aniline (300 mg, 1.27 mmol, 1 equiv), trifluoroacetic acid (290 mg, 2.57 mmol, 2.00 equiv, 98%), 2-chloro-N-methylpyrimidin-4-amine (182 mg, 1.27 mmol, 1 equiv), isopropanol (15 mL). The resulting solution was stirred for 3 h at 90 C in an oil bath. The resulting mixture was concentrated under vacuum. The crude product was applied onto a silica gel column with NH4HC03:ACN (1 : 1), Detector, UV 254 nm. This resulted in 23 mg (5%) of (S)-N2-(4-methoxy-3-((l-methylpyrrolidin-3-yl)methoxy)phenyl)- N4-methylpyrimidine-2,4-diamine El (arbitrarily assigned, S) and 22.7 mg (5%) of (R)-N2- (4-methoxy-3-((l-methylpyrrolidin-3-yl)methoxy)phenyl)-N4-methylpyrimidine-2,4-di amine E2 (arbitrarily assigned, R) as a white solid.
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Reference:
Patent; EPIZYME, INC.; CAMPBELL, John Emmerson; DUNCAN, Kenneth William; FOLEY, Megan Alene; HARVEY, Darren Martin; KUNTZ, Kevin Wayne; MILLS, James Edward John; MUNCHHOF, Michael John; (586 pag.)WO2017/181177; (2017); A1;,
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