Application of 1780-26-3, Adding some certain compound to certain chemical reactions, such as: 1780-26-3, name is 2-Methyl-4,6-dichloropyrimidine,molecular formula is C5H4Cl2N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1780-26-3.
A suspension of compound 16 (4.0 g, 23.2 mmol) and Cs2CO3 (15.14 g, 46.5 mmol) in 116 ml DMF were stirred at 0 C, compound 12 (5.68 g, 34.8 mmol) were added to the mixture in portion. The reaction mixture was stirred at 0 for 5 min , then stirred at room temperature for 8 h. The suspension was poured into 580 ml ice-water and fiercely stirred about 30 min to give a precipitate. The precipitate was ltered and washed with water and ethyl acetate, then dried under vacuum to aord the desired compound 17 (5.67 g, 82%) as a light yellow solid. 1H-NMR (400 MHz, DMSO-d6): delta 12.38 (s, 1H), 8.15 (s, 1H), 6.95 (s ,1H), 4.30 (q, J = 7.2 HZ, 2H), 2.60 (s, 3H), 1.30 (t, J = 7.2 HZ, 3H).
According to the analysis of related databases, 1780-26-3, the application of this compound in the production field has become more and more popular.
Reference:
Article; Li, Hui-ying; He, Ding-Di; Zhao, Xiu-Juan; Sun, Tong-Yan; Zhang, Quan; Bai, Cui-Gai; Chen, Yue; Bioorganic and Medicinal Chemistry Letters; vol. 28; 4; (2018); p. 700 – 706;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia