Application of 117516-97-9 , The common heterocyclic compound, 117516-97-9, name is 2-Thioxo-2,3-dihydrothieno[2,3-d]pyrimidin-4(1H)-one, molecular formula is C6H4N2OS2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: A suspension of 94 (78 mg, 0.399 mmol, 1.0eq) and NEt3 (66 muL, 0.479 mmol, 1.2 eq) in 1.0 mL DMF was stirred for 15 min at room temperature before 954 (150 mg, 0.479 mmol, 1.2 eq) was added and the reaction mixture was stirred for 16 h at room temperature. The solids were filtered, washed with small amounts of water, methanol and diethyl ether,and the product was dried under vacuum to give the corresponding methyl ester (131 mg, 77%) as a whitesolid, which was subsequently hydrolyzed.
The synthetic route of 117516-97-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Fuerst, Rita; Yong Choi, Jun; Knapinska, Anna M.; Smith, Lyndsay; Cameron, Michael D.; Ruiz, Claudia; Fields, Gregg B.; Roush, William R.; Bioorganic and Medicinal Chemistry; vol. 26; 18; (2018); p. 4984 – 4995;,
Pyrimidine | C4H4N2 – PubChem,
Pyrimidine – Wikipedia